Crotonylation versus acetylation
نویسندگان
چکیده
منابع مشابه
Histone lysine-crotonylation in acute kidney injury
Acute kidney injury (AKI) is a potentially lethal condition for which no therapy is available beyond replacement of renal function. Post-translational histone modifications modulate gene expression and kidney injury. Histone crotonylation is a recently described post-translational modification. We hypothesized that histone crotonylation may modulate kidney injury. Histone crotonylation was stud...
متن کاملHistone methylation versus histone acetylation: new insights into epigenetic regulation.
Post-translational addition of methyl groups to the amino-terminal tails of histone proteins was discovered more than three decades ago. Only now, however, is the biological significance of lysine and arginine methylation of histone tails being elucidated. Recent findings indicate that methylation of certain core histones is catalyzed by a family of conserved proteins known as the histone methy...
متن کاملReading and Interpreting the Histone Acylation Code
Decades of research has explored the epigenetic control of gene expression and the impact of histone post-translational modifications (PTMs), such as acetylation, on chromatin remodeling. Indeed, the writers, readers, and erasers of lysine acetylation are increasingly well understood. Recent studies have added crotonylation, butyrylation, and propionylation to the types of acylations by which h...
متن کاملYEATS domain: Linking histone crotonylation to gene regulation
Recent research reveals that the YEATS domains preferentially recognize crotonylated lysines on histones. Here, we discuss the molecular mechanisms that enable this recognition and the biological significances of this interaction. The dynamics of histone crotonylation and its potential roles in the regulation of gene expression will also be discussed.
متن کاملHistone lysine crotonylation during acute kidney injury in mice
Acute kidney injury (AKI) is a potentially lethal condition for which no therapy is available beyond replacement of renal function. Post-translational histone modifications modulate gene expression and kidney injury. Histone crotonylation is a recently described post-translational modification. We hypothesized that histone crotonylation might modulate kidney injury. Histone crotonylation was st...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2015
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3992